Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes

Bloom's syndrome helicase (BLM) is a member of the RecQ family of DNA helicases, which play key roles in the maintenance of genome integrity in all organism groups. We describe crystal structures of the BLM helicase domain in complex with DNA and with an antibody fragment, as well as SAXS and d...

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Detalles Bibliográficos
Autores principales: Newman, Joseph A., Savitsky, Pavel, Allerston, Charles K., Bizard, Anna H., Özer, Özgün, Sarlós, Kata, Liu, Ying, Pardon, Els, Steyaert, Jan, Hickson, Ian D., Gileadi, Opher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446433/
https://www.ncbi.nlm.nih.gov/pubmed/25901030
http://dx.doi.org/10.1093/nar/gkv373

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446433/
https://www.ncbi.nlm.nih.gov/pubmed/25901030
http://dx.doi.org/10.1093/nar/gkv373

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