Interspecific adaptation by binary choice at de novo polyomavirus T antigen site through accelerated codon-constrained Val-Ala toggling within an intrinsically disordered region

It is common knowledge that conserved residues evolve slowly. We challenge generality of this central tenet of molecular biology by describing the fast evolution of a conserved nucleotide position that is located in the overlap of two open reading frames (ORFs) of polyomaviruses. The de novo ORF is...

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Detalles Bibliográficos
Autores principales: Lauber, Chris, Kazem, Siamaque, Kravchenko, Alexander A., Feltkamp, Mariet C.W., Gorbalenya, Alexander E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446436/
https://www.ncbi.nlm.nih.gov/pubmed/25904630
http://dx.doi.org/10.1093/nar/gkv378

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446436/
https://www.ncbi.nlm.nih.gov/pubmed/25904630
http://dx.doi.org/10.1093/nar/gkv378

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