Cargando…

Cyclovirobuxine D Attenuates Doxorubicin-Induced Cardiomyopathy by Suppression of Oxidative Damage and Mitochondrial Biogenesis Impairment

The clinical application of doxorubicin (DOX) is compromised by its cardiac toxic effect. Cyclovirobuxine D (CVB-D) is a steroid alkaloid extracted from a traditional Chinese medicine, Buxus microphylla. Our results showed that CVB-D pretreatment markedly attenuated DOX-induced cardiac contractile d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guo, Qian, Guo, Jiabin, Yang, Rong, Peng, Hui, Zhao, Jun, Li, Li, Peng, Shuangqing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446494/ https://www.ncbi.nlm.nih.gov/pubmed/26075032 http://dx.doi.org/10.1155/2015/151972

Ejemplares similares

Zinc Oxide Nanoparticles Induce Mitochondrial Biogenesis Impairment and Cardiac Dysfunction in Human iPSC-Derived Cardiomyocytes
por: Li, Yujie, et al.
Publicado: (2020)

Cyclovirobuxine D Induces Apoptosis and Mitochondrial Damage in Glioblastoma Cells Through ROS-Mediated Mitochondrial Translocation of Cofilin
por: Zhang, Lin, et al.
Publicado: (2021)

Cyclovirobuxine D Ameliorates Experimental Diabetic Cardiomyopathy by Inhibiting Cardiomyocyte Pyroptosis via NLRP3 in vivo and in vitro
por: Gao, Ge, et al.
Publicado: (2022)

Cyclovirobuxine D protects against diabetic cardiomyopathy by activating Nrf2-mediated antioxidant responses
por: Jiang, Zhaohui, et al.
Publicado: (2020)

Cyclovirobuxine D pretreatment ameliorates septic heart injury through mitigation of ferroptosis
por: Wang, Jianxin, et al.
Publicado: (2023)

The Role of Mitochondrial Biogenesis Dysfunction in Diabetic Cardiomyopathy
por: Tao, Li-Chan, et al.
Publicado: (2022)

Impairment of Mitochondrial Biogenesis and Dynamics Involved in Isoniazid-Induced Apoptosis of HepG2 Cells Was Alleviated by p38 MAPK Pathway
por: Zhang, Tianguang, et al.
Publicado: (2017)

Dilated cardiomyopathy impairs mitochondrial biogenesis and promotes inflammation in an age- and sex-dependent manner
por: Barcena, Maria Luisa, et al.
Publicado: (2020)

Cyclovirobuxine D inhibits cell proliferation and migration and induces apoptosis in human glioblastoma multiforme and low-grade glioma
por: Zhou, Lingqi, et al.
Publicado: (2020)

Design and optimization of self-nanoemulsifying drug delivery systems for improved bioavailability of cyclovirobuxine D
por: Ke, Zhongcheng, et al.
Publicado: (2016)

Cyclovirobuxine inhibits the progression of clear cell renal cell carcinoma by suppressing the IGFBP3-AKT/STAT3/MAPK-Snail signalling pathway
por: Liu, Yadong, et al.
Publicado: (2021)

DNA repair pathways-targeted cyclovirobuxine inhibits castration-resistant prostate cancer growth by promoting cell apoptosis and cycle arrest
por: Gao, Ke, et al.
Publicado: (2023)

Empagliflozin attenuates doxorubicin-induced cardiotoxicity by activating AMPK/SIRT-1/PGC-1α-mediated mitochondrial biogenesis
por: Chen, Meicong
Publicado: (2023)

LATS2 Deletion Attenuates Myocardial Ischemia-Reperfusion Injury by Promoting Mitochondrial Biogenesis
por: Chen, Yi, et al.
Publicado: (2021)

Yap1 modulates cardiomyocyte hypertrophy via impaired mitochondrial biogenesis in response to chronic mechanical stress overload
por: Yue, Peng, et al.
Publicado: (2022)

Cyclovirobuxine D inhibits colorectal cancer tumorigenesis via the CTHRC1-AKT/ERK-Snail signaling pathway
por: Jiang, Fengqi, et al.
Publicado: (2020)

Protective Effect of Qiliqiangxin against Doxorubicin-Induced Cardiomyopathy by Suppressing Excessive Autophagy and Apoptosis
por: Qin, Yating, et al.
Publicado: (2022)

Cyclovirobuxine D Inhibits Cell Proliferation and Induces Mitochondria-Mediated Apoptosis in Human Gastric Cancer Cells
por: Wu, Jie, et al.
Publicado: (2015)

SFRP2 Improves Mitochondrial Dynamics and Mitochondrial Biogenesis, Oxidative Stress, and Apoptosis in Diabetic Cardiomyopathy
por: Ma, Tianyi, et al.
Publicado: (2021)

Histone Demethylase JMJD3 Mediated Doxorubicin-Induced Cardiomyopathy by Suppressing SESN2 Expression
por: Wang, Panxia, et al.
Publicado: (2020)

Attenuation of diabetic cardiomyopathy by relying on kirenol to suppress inflammation in a diabetic rat model
por: Wu, Bin, et al.
Publicado: (2019)

Multiple mitochondria-targeted components screened from Sini decoction improved cardiac energetics and mitochondrial dysfunction to attenuate doxorubicin-induced cardiomyopathy
por: Ding, Xin, et al.
Publicado: (2023)

Resveratrol Regulates Mitochondrial Biogenesis and Fission/Fusion to Attenuate Rotenone-Induced Neurotoxicity
por: Peng, Kaige, et al.
Publicado: (2016)

A Noradrenergic Lesion Attenuates Surgery-Induced Cognitive Impairment in Rats by Suppressing Neuroinflammation
por: Wang, Jiayu, et al.
Publicado: (2021)

Modeling Doxorubicin-Induced Cardiomyopathy With Fibrotic Myocardial Damage in Wistar Rats
por: Podyacheva, Ekaterina, et al.
Publicado: (2022)

Crosstalk between mitochondrial biogenesis and mitophagy to maintain mitochondrial homeostasis
por: Liu, Lei, et al.
Publicado: (2023)

Delivery of astragalus polysaccharide by ultrasound microbubbles attenuate doxorubicin-induced cardiomyopathy in rodent animals
por: Liu, Yanjie, et al.
Publicado: (2022)

Major vault protein attenuates cardiomyocyte injury in doxorubicin-induced cardiomyopathy through activating AKT
por: Qi, Yu, et al.
Publicado: (2022)

Qishen Granule Protects against Doxorubicin-Induced Cardiotoxicity by Coordinating MDM2-p53-Mediated Mitophagy and Mitochondrial Biogenesis
por: Li, Weili, et al.
Publicado: (2022)

Mitochondrial Fe-S cluster biogenesis, frataxin and the modulation of susceptibility to drug-induced cardiomyopathy
por: Sack, Michael N.
Publicado: (2010)

Mitochondrial therapy for doxorubicin cardiomyopathy: nuclear factor-κB to the rescue?
por: Nijholt, Kirsten Theresa, et al.
Publicado: (2020)

In situ observation of mitochondrial biogenesis as the early event of apoptosis
por: Shao, Chang-Sheng, et al.
Publicado: (2021)

Gas signaling molecule hydrogen sulfide attenuates doxorubicin-induced dilated cardiomyopathy
por: Yu, Zongliang, et al.
Publicado: (2017)

Melatonin prevents doxorubicin-induced cardiotoxicity through suppression of AMPKα2-dependent mitochondrial damage
por: Yang, Goowon, et al.
Publicado: (2020)

Euxanthone improves cognitive impairment by attenuating mitochondrial fragmentation and suppressing oxidative stress
por: Sun, Wei, et al.
Publicado: (2021)

Luteolin Attenuates Doxorubicin-Induced Cardiotoxicity Through Promoting Mitochondrial Autophagy
por: Xu, Haixia, et al.
Publicado: (2020)

Protective role of p53 in doxorubicin-induced cardiomyopathy as a mitochondrial disease
por: Nishi, Masahiro, et al.
Publicado: (2020)

Melatonin improves mitochondrial biogenesis through the AMPK/PGC1α pathway to attenuate ischemia/reperfusion-induced myocardial damage
por: Qi, Xueyan, et al.
Publicado: (2020)

Carnosine attenuates cyclophosphamide-induced bone marrow suppression by reducing oxidative DNA damage
por: Deng, Jie, et al.
Publicado: (2017)

mito-TEMPO Attenuates Oxidative Stress and Mitochondrial Dysfunction in Noise-Induced Hearing Loss via Maintaining TFAM-mtDNA Interaction and Mitochondrial Biogenesis
por: Chen, Jia-Wei, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_7ustuhborr6lbnjulhkeqd296u