Cargando…

Anti-Obese Effect of Glucosamine and Chitosan Oligosaccharide in High-Fat Diet-Induced Obese Rats

Objective: This study is to evaluate the anti-obese effects of glucosamine (GLC) and chitosan oligosaccharide (COS) on high-fat diet-induced obese rats. Methods: The rats were randomly divided into twelve groups: a normal diet group (NF), a high-fat diet group (HF), Orlistat group, GLC high-, middle...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Lanlan, Chen, Jian, Cao, Peiqiu, Pan, Haitao, Ding, Chen, Xiao, Tiancun, Zhang, Pengfei, Guo, Jiao, Su, Zhengquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446603/
https://www.ncbi.nlm.nih.gov/pubmed/25942093
http://dx.doi.org/10.3390/md13052732
_version_ 1782373461981659136
author Huang, Lanlan
Chen, Jian
Cao, Peiqiu
Pan, Haitao
Ding, Chen
Xiao, Tiancun
Zhang, Pengfei
Guo, Jiao
Su, Zhengquan
author_facet Huang, Lanlan
Chen, Jian
Cao, Peiqiu
Pan, Haitao
Ding, Chen
Xiao, Tiancun
Zhang, Pengfei
Guo, Jiao
Su, Zhengquan
author_sort Huang, Lanlan
collection PubMed
description Objective: This study is to evaluate the anti-obese effects of glucosamine (GLC) and chitosan oligosaccharide (COS) on high-fat diet-induced obese rats. Methods: The rats were randomly divided into twelve groups: a normal diet group (NF), a high-fat diet group (HF), Orlistat group, GLC high-, middle-, and low-dose groups (GLC-H, GLC-M, GLC-L), COS1 (COS, number-average molecular weight ≤1000) high-, middle-, and low-dose groups (COS1-H, COS1-M, COS1-L), and COS2 (COS, number-average molecular weight ≤3000) high-, middle-, and low-dose groups (COS2-H, COS2-M, COS2-L). All groups received oral treatment by gavage once daily for a period of six weeks. Results: Rats fed with COS1 gained the least weight among all the groups (P < 0.01), and these rats lost more weight than those treated with Orlistat. In addition to the COS2-H and Orlistat groups, the serum total cholesterol (CHO) and low-density lipoprotein cholesterol (LDL-C) levels were significantly reduced in all treatment groups compared to the HF group (P < 0.01). The various doses of GLC, COS1 and COS2 reduced the expression levels of PPARγ and LXRα mRNA in the white adipose tissue. Conclusions: The results above demonstrated that GLC, COS1, and COS2 improved dyslipidemia and prevented body weight gains by inhibiting the adipocyte differentiation in obese rats induced by a high-fat diet. Thus, these agents may potentially be used to treat obesity.
format Online
Article
Text
id pubmed-4446603
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-44466032015-05-29 Anti-Obese Effect of Glucosamine and Chitosan Oligosaccharide in High-Fat Diet-Induced Obese Rats Huang, Lanlan Chen, Jian Cao, Peiqiu Pan, Haitao Ding, Chen Xiao, Tiancun Zhang, Pengfei Guo, Jiao Su, Zhengquan Mar Drugs Article Objective: This study is to evaluate the anti-obese effects of glucosamine (GLC) and chitosan oligosaccharide (COS) on high-fat diet-induced obese rats. Methods: The rats were randomly divided into twelve groups: a normal diet group (NF), a high-fat diet group (HF), Orlistat group, GLC high-, middle-, and low-dose groups (GLC-H, GLC-M, GLC-L), COS1 (COS, number-average molecular weight ≤1000) high-, middle-, and low-dose groups (COS1-H, COS1-M, COS1-L), and COS2 (COS, number-average molecular weight ≤3000) high-, middle-, and low-dose groups (COS2-H, COS2-M, COS2-L). All groups received oral treatment by gavage once daily for a period of six weeks. Results: Rats fed with COS1 gained the least weight among all the groups (P < 0.01), and these rats lost more weight than those treated with Orlistat. In addition to the COS2-H and Orlistat groups, the serum total cholesterol (CHO) and low-density lipoprotein cholesterol (LDL-C) levels were significantly reduced in all treatment groups compared to the HF group (P < 0.01). The various doses of GLC, COS1 and COS2 reduced the expression levels of PPARγ and LXRα mRNA in the white adipose tissue. Conclusions: The results above demonstrated that GLC, COS1, and COS2 improved dyslipidemia and prevented body weight gains by inhibiting the adipocyte differentiation in obese rats induced by a high-fat diet. Thus, these agents may potentially be used to treat obesity. MDPI 2015-04-30 /pmc/articles/PMC4446603/ /pubmed/25942093 http://dx.doi.org/10.3390/md13052732 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Huang, Lanlan
Chen, Jian
Cao, Peiqiu
Pan, Haitao
Ding, Chen
Xiao, Tiancun
Zhang, Pengfei
Guo, Jiao
Su, Zhengquan
Anti-Obese Effect of Glucosamine and Chitosan Oligosaccharide in High-Fat Diet-Induced Obese Rats
title Anti-Obese Effect of Glucosamine and Chitosan Oligosaccharide in High-Fat Diet-Induced Obese Rats
title_full Anti-Obese Effect of Glucosamine and Chitosan Oligosaccharide in High-Fat Diet-Induced Obese Rats
title_fullStr Anti-Obese Effect of Glucosamine and Chitosan Oligosaccharide in High-Fat Diet-Induced Obese Rats
title_full_unstemmed Anti-Obese Effect of Glucosamine and Chitosan Oligosaccharide in High-Fat Diet-Induced Obese Rats
title_short Anti-Obese Effect of Glucosamine and Chitosan Oligosaccharide in High-Fat Diet-Induced Obese Rats
title_sort anti-obese effect of glucosamine and chitosan oligosaccharide in high-fat diet-induced obese rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446603/
https://www.ncbi.nlm.nih.gov/pubmed/25942093
http://dx.doi.org/10.3390/md13052732
work_keys_str_mv AT huanglanlan antiobeseeffectofglucosamineandchitosanoligosaccharideinhighfatdietinducedobeserats
AT chenjian antiobeseeffectofglucosamineandchitosanoligosaccharideinhighfatdietinducedobeserats
AT caopeiqiu antiobeseeffectofglucosamineandchitosanoligosaccharideinhighfatdietinducedobeserats
AT panhaitao antiobeseeffectofglucosamineandchitosanoligosaccharideinhighfatdietinducedobeserats
AT dingchen antiobeseeffectofglucosamineandchitosanoligosaccharideinhighfatdietinducedobeserats
AT xiaotiancun antiobeseeffectofglucosamineandchitosanoligosaccharideinhighfatdietinducedobeserats
AT zhangpengfei antiobeseeffectofglucosamineandchitosanoligosaccharideinhighfatdietinducedobeserats
AT guojiao antiobeseeffectofglucosamineandchitosanoligosaccharideinhighfatdietinducedobeserats
AT suzhengquan antiobeseeffectofglucosamineandchitosanoligosaccharideinhighfatdietinducedobeserats