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Inhibition of RORγt activity and Th17 differentiation by a set of novel compounds
BACKGROUND: Retinoic acid receptor-related orphan receptor gamma t (RORγt) is the master regulator of Th17 cell differentiation, which plays a critical role in the pathology of several autoimmune diseases. By directing Th17 cells function, RORγt could be a potential target for drug development for T...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446823/ https://www.ncbi.nlm.nih.gov/pubmed/26021566 http://dx.doi.org/10.1186/s12865-015-0097-9 |