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Geometric Constraints Dominate the Antigenic Evolution of Influenza H3N2 Hemagglutinin
We have carried out a comprehensive analysis of the determinants of human influenza A H3 hemagglutinin evolution. We consider three distinct predictors of evolutionary variation at individual sites: solvent accessibility (as a proxy for protein fold stability and/or conservation), Immune Epitope Dat...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447415/ https://www.ncbi.nlm.nih.gov/pubmed/26020774 http://dx.doi.org/10.1371/journal.ppat.1004940 |