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Geometric Constraints Dominate the Antigenic Evolution of Influenza H3N2 Hemagglutinin

We have carried out a comprehensive analysis of the determinants of human influenza A H3 hemagglutinin evolution. We consider three distinct predictors of evolutionary variation at individual sites: solvent accessibility (as a proxy for protein fold stability and/or conservation), Immune Epitope Dat...

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Detalles Bibliográficos
Autores principales: Meyer, Austin G., Wilke, Claus O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447415/
https://www.ncbi.nlm.nih.gov/pubmed/26020774
http://dx.doi.org/10.1371/journal.ppat.1004940

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