eIF1A augments Ago2-mediated Dicer-independent miRNA biogenesis and RNA interference

MicroRNA (miRNA) biogenesis and miRNA-guided RNA interference (RNAi) are essential for gene expression in eukaryotes. Here we report that translation initiation factor eIF1A directly interacts with Ago2 and promotes Ago2 activities in RNAi and miR-451 biogenesis. Biochemical and NMR analyses demonst...

Descripción completa

Detalles Bibliográficos
Autores principales: Yi, Tingfang, Arthanari, Haribabu, Akabayov, Barak, Song, Huaidong, Papadopoulos, Evangelos, Qi, Hank H., Jedrychowski, Mark, Güttler, Thomas, Guo, Cuicui, Luna, Rafael E., Gygi, Steven P., Huang, Stephen A., Wagner, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448125/
https://www.ncbi.nlm.nih.gov/pubmed/26018492
http://dx.doi.org/10.1038/ncomms8194

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448125/
https://www.ncbi.nlm.nih.gov/pubmed/26018492
http://dx.doi.org/10.1038/ncomms8194

Ejemplares similares