The Cullin 4A/B-DDB1-Cereblon E3 Ubiquitin Ligase Complex Mediates the Degradation of CLC-1 Chloride Channels

Voltage-gated CLC-1 chloride channels play a critical role in controlling the membrane excitability of skeletal muscles. Mutations in human CLC-1 channels have been linked to the hereditary muscle disorder myotonia congenita. We have previously demonstrated that disease-associated CLC-1 A531V mutant...

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Detalles Bibliográficos
Autores principales: Chen, Yi-An, Peng, Yi-Jheng, Hu, Meng-Chun, Huang, Jing-Jia, Chien, Yun-Chia, Wu, June-Tai, Chen, Tsung-Yu, Tang, Chih-Yung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448132/
https://www.ncbi.nlm.nih.gov/pubmed/26021757
http://dx.doi.org/10.1038/srep10667

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448132/
https://www.ncbi.nlm.nih.gov/pubmed/26021757
http://dx.doi.org/10.1038/srep10667

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