Vaccine-induced Aβ-specific CD8(+) T cells do not trigger autoimmune neuroinflammation in a murine model of Alzheimer’s disease

BACKGROUND: Active immunization against Aβ was reported to have a therapeutic effect in murine models of Alzheimer’s disease. Clinical Aβ vaccination trial AN1792 was interrupted due to the development in 6 % of the patients of meningoencephalitis likely involving pro-inflammatory CD4(+) T cells. Ho...

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Detalles Bibliográficos
Autores principales: Rosset, Martine Bruley, Lui, Gabrielle, Dansokho, Cira, Chaigneau, Thomas, Dorothée, Guillaume
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448209/
https://www.ncbi.nlm.nih.gov/pubmed/25982697
http://dx.doi.org/10.1186/s12974-015-0317-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448209/
https://www.ncbi.nlm.nih.gov/pubmed/25982697
http://dx.doi.org/10.1186/s12974-015-0317-5

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