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Pharmacokinetic profile of paclitaxel in the plasma, lung, and diaphragm following intravenous or intrapleural administration in rats

BACKGROUND: The optimal chemotherapy route for non-small cell lung cancers involving the phrenic nerve and diaphragm is unclear. The pharmacokinetic properties of paclitaxel following intravenous (IV) or intrapleural (IP) administration were analyzed in the plasma, lung, and diaphragm in a rat model...

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Detalles Bibliográficos
Autores principales: Li, Jie, Tang, Jian, Li, Yingjie, Yu, Jianqi, Zhang, Baoshi, Yu, Changhai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448465/
https://www.ncbi.nlm.nih.gov/pubmed/26273334
http://dx.doi.org/10.1111/1759-7714.12139