A top-down view of the tumor microenvironment: structure, cells and signaling

It is well established that the tumor microenvironment (TME) contributes to cancer progression. Stromal cells can be divided into mesenchymal, vascular, and immune. Signaling molecules secreted by the tumor corrupts these cells to create “activated” stroma. Equally, the extracellular matrix (ECM) co...

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Detalles Bibliográficos
Autores principales: Bhome, Rahul, Bullock, Marc D., Al Saihati, Hajir A., Goh, Rebecca W., Primrose, John N., Sayan, A. Emre, Mirnezami, Alex H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448519/
https://www.ncbi.nlm.nih.gov/pubmed/26075202
http://dx.doi.org/10.3389/fcell.2015.00033
Descripción
Sumario:It is well established that the tumor microenvironment (TME) contributes to cancer progression. Stromal cells can be divided into mesenchymal, vascular, and immune. Signaling molecules secreted by the tumor corrupts these cells to create “activated” stroma. Equally, the extracellular matrix (ECM) contributes to tumor development and invasion by forming a biologically active scaffold. In this review we describe the key structural, cellular and signaling components of the TME with a perspective on stromal soluble factors and microRNAs (miRNAs).

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