A top-down view of the tumor microenvironment: structure, cells and signaling

It is well established that the tumor microenvironment (TME) contributes to cancer progression. Stromal cells can be divided into mesenchymal, vascular, and immune. Signaling molecules secreted by the tumor corrupts these cells to create “activated” stroma. Equally, the extracellular matrix (ECM) co...

Descripción completa

Detalles Bibliográficos
Autores principales: Bhome, Rahul, Bullock, Marc D., Al Saihati, Hajir A., Goh, Rebecca W., Primrose, John N., Sayan, A. Emre, Mirnezami, Alex H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448519/
https://www.ncbi.nlm.nih.gov/pubmed/26075202
http://dx.doi.org/10.3389/fcell.2015.00033
_version_ 1782373719598956544
author Bhome, Rahul
Bullock, Marc D.
Al Saihati, Hajir A.
Goh, Rebecca W.
Primrose, John N.
Sayan, A. Emre
Mirnezami, Alex H.
author_facet Bhome, Rahul
Bullock, Marc D.
Al Saihati, Hajir A.
Goh, Rebecca W.
Primrose, John N.
Sayan, A. Emre
Mirnezami, Alex H.
author_sort Bhome, Rahul
collection PubMed
description It is well established that the tumor microenvironment (TME) contributes to cancer progression. Stromal cells can be divided into mesenchymal, vascular, and immune. Signaling molecules secreted by the tumor corrupts these cells to create “activated” stroma. Equally, the extracellular matrix (ECM) contributes to tumor development and invasion by forming a biologically active scaffold. In this review we describe the key structural, cellular and signaling components of the TME with a perspective on stromal soluble factors and microRNAs (miRNAs).
format Online
Article
Text
id pubmed-4448519
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-44485192015-06-12 A top-down view of the tumor microenvironment: structure, cells and signaling Bhome, Rahul Bullock, Marc D. Al Saihati, Hajir A. Goh, Rebecca W. Primrose, John N. Sayan, A. Emre Mirnezami, Alex H. Front Cell Dev Biol Oncology It is well established that the tumor microenvironment (TME) contributes to cancer progression. Stromal cells can be divided into mesenchymal, vascular, and immune. Signaling molecules secreted by the tumor corrupts these cells to create “activated” stroma. Equally, the extracellular matrix (ECM) contributes to tumor development and invasion by forming a biologically active scaffold. In this review we describe the key structural, cellular and signaling components of the TME with a perspective on stromal soluble factors and microRNAs (miRNAs). Frontiers Media S.A. 2015-05-29 /pmc/articles/PMC4448519/ /pubmed/26075202 http://dx.doi.org/10.3389/fcell.2015.00033 Text en Copyright © 2015 Bhome, Bullock, Al Saihati, Goh, Primrose, Sayan and Mirnezami. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Bhome, Rahul
Bullock, Marc D.
Al Saihati, Hajir A.
Goh, Rebecca W.
Primrose, John N.
Sayan, A. Emre
Mirnezami, Alex H.
A top-down view of the tumor microenvironment: structure, cells and signaling
title A top-down view of the tumor microenvironment: structure, cells and signaling
title_full A top-down view of the tumor microenvironment: structure, cells and signaling
title_fullStr A top-down view of the tumor microenvironment: structure, cells and signaling
title_full_unstemmed A top-down view of the tumor microenvironment: structure, cells and signaling
title_short A top-down view of the tumor microenvironment: structure, cells and signaling
title_sort top-down view of the tumor microenvironment: structure, cells and signaling
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448519/
https://www.ncbi.nlm.nih.gov/pubmed/26075202
http://dx.doi.org/10.3389/fcell.2015.00033
work_keys_str_mv AT bhomerahul atopdownviewofthetumormicroenvironmentstructurecellsandsignaling
AT bullockmarcd atopdownviewofthetumormicroenvironmentstructurecellsandsignaling
AT alsaihatihajira atopdownviewofthetumormicroenvironmentstructurecellsandsignaling
AT gohrebeccaw atopdownviewofthetumormicroenvironmentstructurecellsandsignaling
AT primrosejohnn atopdownviewofthetumormicroenvironmentstructurecellsandsignaling
AT sayanaemre atopdownviewofthetumormicroenvironmentstructurecellsandsignaling
AT mirnezamialexh atopdownviewofthetumormicroenvironmentstructurecellsandsignaling
AT bhomerahul topdownviewofthetumormicroenvironmentstructurecellsandsignaling
AT bullockmarcd topdownviewofthetumormicroenvironmentstructurecellsandsignaling
AT alsaihatihajira topdownviewofthetumormicroenvironmentstructurecellsandsignaling
AT gohrebeccaw topdownviewofthetumormicroenvironmentstructurecellsandsignaling
AT primrosejohnn topdownviewofthetumormicroenvironmentstructurecellsandsignaling
AT sayanaemre topdownviewofthetumormicroenvironmentstructurecellsandsignaling
AT mirnezamialexh topdownviewofthetumormicroenvironmentstructurecellsandsignaling

Ejemplares similares