Cargando…

Single-Dose Local Simvastatin Injection Improves Implant Fixation via Increased Angiogenesis and Bone Formation in an Ovariectomized Rat Model

BACKGROUND: Statins have been reported to promote bone formation. However, taken orally, their bioavailability is low to the bones. Implant therapies require a local repair response, topical application of osteoinductive agents, or biomaterials that promote implant fixation. MATERIAL/METHODS: The pr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tan, Jie, Yang, Ning, Fu, Xin, Cui, Yueyi, Guo, Qi, Ma, Teng, Yin, Xiaoxue, Leng, Huijie, Song, Chunli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Scientific Literature, Inc. 2015
Materias:	Animal Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448596/ https://www.ncbi.nlm.nih.gov/pubmed/25982481 http://dx.doi.org/10.12659/MSM.892247

Ejemplares similares

Simvastatin-hydroxyapatite coatings prevent biofilm formation and improve bone formation in implant-associated infections
por: Sun, Tiantong, et al.
Publicado: (2022)

Influence of Simvastatin-Loaded Implants on Osseointegration in an Ovariectomized Animal Model
por: Fang, Wen, et al.
Publicado: (2015)

Effect of simvastatin on osteogenesis of the lumbar vertebrae in ovariectomized rats
por: Long, Teng, et al.
Publicado: (2016)

Pleiotropic effects of simvastatin in physically trained ovariectomized rats
por: Bernardes, N., et al.
Publicado: (2013)

Icariin Promotes Fracture Healing in Ovariectomized Rats
por: Zhang, Yong, et al.
Publicado: (2020)

Protective Effect of Alendronate on Lumbar Facet Degeneration in Ovariectomized Rats
por: Zhang, Nan, et al.
Publicado: (2019)

Effects of Drynaria Total Flavonoid on the Microstructure of the Mandible in Ovariectomized Rats
por: Zeng, Hui, et al.
Publicado: (2020)

Single-dose local intraosseous injection of simvastatin suppresses breast cancer with tumor vascular normalization
por: Yuan, Wanqiong, et al.
Publicado: (2020)

Estrogen Modulates Cartilage and Subchondral Bone Remodeling in an Ovariectomized Rat Model of Postmenopausal Osteoarthritis
por: Xu, Xiao, et al.
Publicado: (2019)

Short-Term Hypoxia Accelerates Bone Loss in Ovariectomized Rats by Suppressing Osteoblastogenesis but Enhancing Osteoclastogenesis
por: Wang, Guixin, et al.
Publicado: (2016)

Strontium Ranelate Combined with Insulin Is as Beneficial as Insulin Alone in Treatment of Fracture Healing in Ovariectomized Diabetic Rats
por: Cao, Guo-Long, et al.
Publicado: (2018)

Effect of a local, one time, low-dose injection of zoledronic acid on titanium implant osseointegration in ovariectomized rats
por: Ying, Gao, et al.
Publicado: (2016)

Cardiac Hypertrophy and Brain Natriuretic Peptide Levels in an Ovariectomized Rat Model Fed a High-Fat Diet
por: Goncalves, Gleisy Kelly, et al.
Publicado: (2017)

Injectable Tissue-Engineered Pulmonary Heart Valve Implantation Into the Pig Model: A Feasibility Study
por: Schlegel, Franziska, et al.
Publicado: (2015)

The effects of treadmill exercise on brain angiogenesis in ovariectomized rats
por: Yoon, Eun‐Jung, et al.
Publicado: (2023)

Aucubin Impeded Preosteoclast Fusion and Enhanced CD31(hi) EMCN(hi) Vessel Angiogenesis in Ovariectomized Mice
por: Li, Ziyi, et al.
Publicado: (2022)

Orally administered simvastatin partially preserves lumbar vertebral bone mass but not integrity of intervertebral discs in ovariectomized rats
por: Tian, Fa-Ming, et al.
Publicado: (2017)

Experimental study on the effects of simvastatin in reversing the femoral metaphyseal defects induced by sodium valproate in normal and ovariectomized rats
por: Li, Yang, et al.
Publicado: (2022)

Simvastatin Improves Cardiac Hypertrophy in Diabetic Rats by Attenuation of Oxidative Stress and Inflammation Induced by Calpain-1-Mediated Activation of Nuclear Factor-κB (NF-κB)
por: Han, Qianqian, et al.
Publicado: (2019)

Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist Liraglutide Alters Bone Marrow Exosome-Mediated miRNA Signal Pathways in Ovariectomized Rats with Type 2 Diabetes
por: Li, Jin, et al.
Publicado: (2017)

Angiogenesis Changes in Ovariectomized Rats with Osteoporosis Treated with Estrogen Replacement Therapy
por: Zhang, Yige, et al.
Publicado: (2019)

The effect of osteoprotegerin on implant osseointegration in ovariectomized rats
por: Liu, Yiming, et al.
Publicado: (2017)

Toxicology and Pharmacokinetics Study of Intradiscal Injection of Simvastatin in Rabbits
por: Huang, Xiaodong, et al.
Publicado: (2021)

Does simvastatin stimulate bone formation in vivo?
por: von Stechow, Dietrich, et al.
Publicado: (2003)

RAGE inhibits human respiratory syncytial virus syncytium formation by interfering with F-protein function
por: Tian, Jane, et al.
Publicado: (2013)

Carvedilol Ameliorates Intrahepatic Angiogenesis, Sinusoidal Remodeling and Portal Pressure in Cirrhotic Rats
por: Ling, Liping, et al.
Publicado: (2018)

Simvastatin Reduces Capsular Fibrosis around Silicone Implants
por: Chung, Kyu Jin, et al.
Publicado: (2016)

Effect of lycopene on titanium implant osseointegration in ovariectomized rats
por: Li, Xiaojie, et al.
Publicado: (2018)

Feline calicivirus p32, p39 and p30 proteins localize to the endoplasmic reticulum to initiate replication complex formation
por: Bailey, Dalan, et al.
Publicado: (2010)

EFFECT OF ESTRADIOL INJECTION ON THE CYTOPLASMIC FRACTIONS OF THE MYOMETRIUM IN THE OVARIECTOMIZED RAT
por: Wakid, N. W., et al.
Publicado: (1961)

The effect of topical administration of simvastatin on entochondrostosis and intramembranous ossification: An animal experiment
por: Dang, Lei, et al.
Publicado: (2021)

Impaired bone formation in ovariectomized mice reduces implant integration as indicated by longitudinal in vivo micro-computed tomography
por: Li, Zihui, et al.
Publicado: (2017)

Qishen Yiqi Dropping Pills Ameliorates Doxorubicin-Induced Cardiotoxicity in Mice via Enhancement of Cardiac Angiogenesis
por: Wang, Lijiang, et al.
Publicado: (2019)

Artificial Dermal Scaffold Loaded with Platelet-Rich Plasma Promotes Wound Healing in Pigs by Favoring Angiogenesis
por: Li, Zhi-Hao, et al.
Publicado: (2022)

Effect of weekly teriparatide injections on osteoporotic fracture healing: protocol for a double-blind, randomised controlled trial
por: Zhu, Junxiong, et al.
Publicado: (2021)

Mimic Cochlear Implant Surgery-Induced Cochlear Infection Fails to Further Damage Auditory Pathway in Deafened Guinea Pigs
por: Han, Zhao, et al.
Publicado: (2018)

Sustained-release progesterone nanosuspension following intramuscular injection in ovariectomized rats
por: Salem, Heba F
Publicado: (2010)

Granulocyte-Colony Stimulating Factor (G-CSF) Accelerates Wound Healing in Hemorrhagic Shock Rats by Enhancing Angiogenesis and Attenuating Apoptosis
por: Huang, Hong, et al.
Publicado: (2017)

Asperosaponin VI Injection Enhances Orthodontic Tooth Movement in Rats
por: Ma, Dan, et al.
Publicado: (2020)

Therapeutic Effect of Cistanoside A on Bone Metabolism of Ovariectomized Mice
por: Xu, Xiaoxue, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_tknerbl1v31u9uojeog7d9aj99