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Antagonistic regulation of mRNA expression and splicing by CELF and MBNL proteins

RNA binding proteins of the conserved CUGBP1, Elav-like factor (CELF) family contribute to heart and skeletal muscle development and are implicated in myotonic dystrophy (DM). To understand their genome-wide functions, we analyzed the transcriptome dynamics following induction of CELF1 or CELF2 in a...

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Detalles Bibliográficos
Autores principales: Wang, Eric T., Ward, Amanda J., Cherone, Jennifer M., Giudice, Jimena, Wang, Thomas T., Treacy, Daniel J., Lambert, Nicole J., Freese, Peter, Saxena, Tanvi, Cooper, Thomas A., Burge, Christopher B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448682/
https://www.ncbi.nlm.nih.gov/pubmed/25883322
http://dx.doi.org/10.1101/gr.184390.114