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Genetic barcode sequencing for screening altered population dynamics of hematopoietic stem cells transduced with lentivirus
Insertional mutagenesis has been associated with malignant cell transformation in gene therapy protocols, leading to discussions about vector security. Therefore, clonal analysis is important for the assessment of vector safety and its impact on patient health. Here, we report a unique approach to a...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448734/ https://www.ncbi.nlm.nih.gov/pubmed/26052520 http://dx.doi.org/10.1038/mtm.2014.52 |