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DNA vaccination strategy targets epidermal dendritic cells, initiating their migration and induction of a host immune response

The immunocompetence and clinical accessibility of dermal tissue offers an appropriate and attractive target for vaccination. We previously demonstrated that pDNA injection into the skin in combination with surface electroporation (SEP), results in rapid and robust expression of the encoded antigen...

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Detalles Bibliográficos
Autores principales: Smith, Trevor RF, Schultheis, Katherine, Kiosses, William B, Amante, Dinah H, Mendoza, Janess M, Stone, John C, McCoy, Jay R, Sardesai, Niranjan Y, Broderick, Kate E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448738/
https://www.ncbi.nlm.nih.gov/pubmed/26052522
http://dx.doi.org/10.1038/mtm.2014.54