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Promiscuity progression of bioactive compounds over time

In the context of polypharmacology, compound promiscuity is rationalized as the ability of small molecules to specifically interact with multiple targets. To study promiscuity progression of bioactive compounds in detail, nearly 1 million compounds and more than 5.2 million activity records were ana...

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Detalles Bibliográficos
Autores principales: Hu, Ye, Jasial, Swarit, Bajorath, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448747/
https://www.ncbi.nlm.nih.gov/pubmed/26064479
http://dx.doi.org/10.12688/f1000research.6473.1