Structures of pyruvate kinases display evolutionarily divergent allosteric strategies

The transition between the inactive T-state (apoenzyme) and active R-state (effector bound enzyme) of Trypanosoma cruzi pyruvate kinase (PYK) is accompanied by a symmetrical 8° rigid body rocking motion of the A- and C-domain cores in each of the four subunits, coupled with the formation of addition...

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Detalles Bibliográficos
Autores principales: Morgan, Hugh P., Zhong, Wenhe, McNae, Iain W., Michels, Paul A. M., Fothergill-Gilmore, Linda A., Walkinshaw, Malcolm D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society Publishing 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448766/
https://www.ncbi.nlm.nih.gov/pubmed/26064527
http://dx.doi.org/10.1098/rsos.140120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448766/
https://www.ncbi.nlm.nih.gov/pubmed/26064527
http://dx.doi.org/10.1098/rsos.140120

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