Resident Bacteria-Stimulated Interleukin-10-Secreting B Cells Ameliorate T-Cell-Mediated Colitis by Inducing T-Regulatory-1 Cells That Require Interleukin-27 Signaling

BACKGROUND & AIMS: The regulatory roles of interleukin-10 (IL10)-producing B cells in colitis are not fully understood, so we explored the molecular mechanisms by which these cells modulate mucosal homeostasis. METHODS: CD4(+) T cells from wild-type (WT), Il10(−/−), or Il27ra(−/−) mice were cotr...

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Detalles Bibliográficos
Autores principales: Mishima, Yoshiyuki, Liu, Bo, Hansen, Jonathan J., Sartor, R. Balfour
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448782/
https://www.ncbi.nlm.nih.gov/pubmed/26034781
http://dx.doi.org/10.1016/j.jcmgh.2015.01.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448782/
https://www.ncbi.nlm.nih.gov/pubmed/26034781
http://dx.doi.org/10.1016/j.jcmgh.2015.01.002

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