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Resident Bacteria-Stimulated Interleukin-10-Secreting B Cells Ameliorate T-Cell-Mediated Colitis by Inducing T-Regulatory-1 Cells That Require Interleukin-27 Signaling
BACKGROUND & AIMS: The regulatory roles of interleukin-10 (IL10)-producing B cells in colitis are not fully understood, so we explored the molecular mechanisms by which these cells modulate mucosal homeostasis. METHODS: CD4(+) T cells from wild-type (WT), Il10(−/−), or Il27ra(−/−) mice were cotr...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448782/ https://www.ncbi.nlm.nih.gov/pubmed/26034781 http://dx.doi.org/10.1016/j.jcmgh.2015.01.002 |