Incorporation of concentration data below the limit of quantification in population pharmacokinetic analyses

Handling of data below the lower limit of quantification (LLOQ), below the limit of quantification (BLOQ) in population pharmacokinetic (PopPK) analyses is important for reducing bias and imprecision in parameter estimation. We aimed to evaluate whether using the concentration data below the LLOQ ha...

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Detalles Bibliográficos
Autores principales: Keizer, Ron J, Jansen, Robert S, Rosing, Hilde, Thijssen, Bas, Beijnen, Jos H, Schellens, Jan H M, Huitema, Alwin D R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448983/
https://www.ncbi.nlm.nih.gov/pubmed/26038706
http://dx.doi.org/10.1002/prp2.131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448983/
https://www.ncbi.nlm.nih.gov/pubmed/26038706
http://dx.doi.org/10.1002/prp2.131

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