A novel, long-lived, and highly engraftable immunodeficient mouse model of mucopolysaccharidosis type I

Mucopolysaccharidosis type I (MPS I) is an inherited α-L-iduronidase (IDUA, I) deficiency in which glycosaminoglycan (GAG) accumulation causes progressive multisystem organ dysfunction, neurological impairment, and death. Current MPS I mouse models, based on a NOD/SCID (NS) background, are short-liv...

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Detalles Bibliográficos
Autores principales: Mendez, Daniel C, Stover, Alexander E, Rangel, Anthony D, Brick, David J, Nethercott, Hubert E, Torres, Marissa A, Khalid, Omar, Wong, Andrew MS, Cooper, Jonathan D, Jester, James V, Monuki, Edwin S, McGuire, Cian, Le, Steven Q, Kan, Shih-hsin, Dickson, Patricia I, Schwartz, Philip H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449030/
https://www.ncbi.nlm.nih.gov/pubmed/26052536
http://dx.doi.org/10.1038/mtm.2014.68

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449030/
https://www.ncbi.nlm.nih.gov/pubmed/26052536
http://dx.doi.org/10.1038/mtm.2014.68

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