Structural Dynamics of the Cereblon Ligand Binding Domain

Cereblon, a primary target of thalidomide and its derivatives, has been characterized structurally from both bacteria and animals. Especially well studied is the thalidomide binding domain, CULT, which shows an invariable structure across different organisms and in complex with different ligands. He...

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Detalles Bibliográficos
Autores principales: Hartmann, Marcus D., Boichenko, Iuliia, Coles, Murray, Lupas, Andrei N., Hernandez Alvarez, Birte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449219/
https://www.ncbi.nlm.nih.gov/pubmed/26024445
http://dx.doi.org/10.1371/journal.pone.0128342

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449219/
https://www.ncbi.nlm.nih.gov/pubmed/26024445
http://dx.doi.org/10.1371/journal.pone.0128342

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