Cargando…

Structural Dynamics of the Cereblon Ligand Binding Domain

Cereblon, a primary target of thalidomide and its derivatives, has been characterized structurally from both bacteria and animals. Especially well studied is the thalidomide binding domain, CULT, which shows an invariable structure across different organisms and in complex with different ligands. He...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hartmann, Marcus D., Boichenko, Iuliia, Coles, Murray, Lupas, Andrei N., Hernandez Alvarez, Birte
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449219/ https://www.ncbi.nlm.nih.gov/pubmed/26024445 http://dx.doi.org/10.1371/journal.pone.0128342

Ejemplares similares

Chemical Ligand Space of Cereblon
por: Boichenko, Iuliia, et al.
Publicado: (2018)

The Thalidomide-Binding Domain of Cereblon Defines the CULT Domain Family and Is a New Member of the β-Tent Fold
por: Lupas, Andrei N., et al.
Publicado: (2015)

De-Novo Design of Cereblon (CRBN) Effectors Guided by Natural Hydrolysis Products of Thalidomide Derivatives
por: Heim, Christopher, et al.
Publicado: (2019)

Structural basis of thalidomide enantiomer binding to cereblon
por: Mori, Tomoyuki, et al.
Publicado: (2018)

The breakthrough in protein structure prediction
por: Lupas, Andrei N., et al.
Publicado: (2021)

Accessing three-branched high-affinity cereblon ligands for molecular glue and protein degrader design
por: Kuchta, Robert, et al.
Publicado: (2023)

Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs
por: Steinebach, Christian, et al.
Publicado: (2023)

α/β coiled coils
por: Hartmann, Marcus D, et al.
Publicado: (2016)

In silico analysis of enantioselective binding of immunomodulatory imide drugs to cereblon
por: Murai, Takahiro, et al.
Publicado: (2016)

Homology of SMP domains to the TULIP superfamily of lipid-binding proteins provides a structural basis for lipid exchange between ER and mitochondria
por: Kopec, Klaus O., et al.
Publicado: (2010)

Antiangiogenic Activity and in Silico Cereblon Binding Analysis of Novel Thalidomide Analogs
por: Peach, Megan L., et al.
Publicado: (2020)

Structure of three tandem filamin domains reveals auto-inhibition of ligand binding
por: Lad, Yatish, et al.
Publicado: (2007)

A bi-terminal protein ligation strategy to probe chromatin structure during DNA damage
por: Kilic, Sinan, et al.
Publicado: (2018)

Solution structure and binding specificity of the p63 DNA binding domain
por: Enthart, Andreas, et al.
Publicado: (2016)

Sweet and Blind Spots in E3 Ligase Ligand Space Revealed by a Thermophoresis-Based Assay
por: Maiwald, Samuel, et al.
Publicado: (2020)

Mouse Monoclonal Antibodies Generated from Full Length Human Cereblon: Detection of Cereblon Protein in Patients with Multiple Myeloma
por: Chang, Xiubao, et al.
Publicado: (2017)

Design of novel granulopoietic proteins by topological rescaffolding
por: Hernandez Alvarez, Birte, et al.
Publicado: (2020)

Correction to “Sweet and Blind Spots in E3 Ligase Ligand Space Revealed by a Thermophoresis-Based Assay”
por: Maiwald, Samuel, et al.
Publicado: (2021)

Tubulin Resists Degradation by Cereblon-Recruiting PROTACs
por: Gasic, Ivana, et al.
Publicado: (2020)

UDP-glucose, cereblon-dependent proinsulin degrader
por: Cho, Jaeyong, et al.
Publicado: (2022)

Origin of a folded repeat protein from an intrinsically disordered ancestor
por: Zhu, Hongbo, et al.
Publicado: (2016)

Exploring Ligand Binding Domain Dynamics in the NRs Superfamily
por: D’Arrigo, Giulia, et al.
Publicado: (2022)

Structure and ligand binding of the ADP-binding domain of the NAD(+) riboswitch
por: Huang, Lin, et al.
Publicado: (2020)

Domain annotation of trimeric autotransporter adhesins—daTAA
por: Szczesny, Pawel, et al.
Publicado: (2008)

Cereblon-binding proteins expression levels correlate with hyperdiploidy in newly diagnosed multiple myeloma patients
por: Kriegsmann, Katharina, et al.
Publicado: (2019)

Novel, thalidomide-like, non-cereblon binding drug tetrafluorobornylphthalimide mitigates inflammation and brain injury
por: Lecca, Daniela, et al.
Publicado: (2023)

Structure of the homodimeric androgen receptor ligand-binding domain
por: Nadal, Marta, et al.
Publicado: (2017)

Mitochondrial cereblon functions as a Lon-type protease
por: Kataoka, Kosuke, et al.
Publicado: (2016)

Cereblon covalent modulation through structure-based design of histidine targeting chemical probes
por: Cruite, Justin T., et al.
Publicado: (2022)

Structure and domain dynamics of human lactoferrin in solution and the influence of Fe(III)-ion ligand binding
por: Sill, Clemens, et al.
Publicado: (2016)

A Trimeric Lipoprotein Assists in Trimeric Autotransporter Biogenesis in Enterobacteria
por: Grin, Iwan, et al.
Publicado: (2014)

Susceptibility of pentylenetetrazole-induced seizures in mice with Cereblon gene knockout
por: Jeon, Seung-Je, et al.
Publicado: (2020)

UDP-Glucose: A Cereblon-Dependent Glucokinase Protein Degrader
por: Cho, Jaeyong, et al.
Publicado: (2022)

Targeted protein degradation bypassing cereblon and von Hippel-Lindau
por: Lu, Wenchao
Publicado: (2023)

Conformational Dynamics and Ligand Binding in the Multi-Domain Protein PDC109
por: Kim, Hyun Jin, et al.
Publicado: (2010)

Expression of the cereblon binding protein argonaute 2 plays an important role for multiple myeloma cell growth and survival
por: Xu, Qinqin, et al.
Publicado: (2016)

Structural diversity of oligomeric β-propellers with different numbers of identical blades
por: Afanasieva, Evgenia, et al.
Publicado: (2019)

Ligand Binding and Crystal Structures of the Substrate-Binding Domain of the ABC Transporter OpuA
por: Wolters, Justina C., et al.
Publicado: (2010)

Modeling the binding of diverse ligands within the Ah receptor ligand binding domain
por: Giani Tagliabue, Sara, et al.
Publicado: (2019)

Structural landscape of the isolated ligand binding domain of single AMPA receptors
por: Landes, Christy F., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_58m7vh6eqb6ap4l5v7hniblmte