DNA replication fidelity in Mycobacterium tuberculosis is mediated by an ancestral prokaryotic proofreader

The DNA replication machinery is an important target for antibiotic development for increasingly drug resistant bacteria including Mycobacterium tuberculosis(1). While blocking DNA replication leads to cell death, disrupting the processes used to ensure replication fidelity can accelerate mutation a...

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Detalles Bibliográficos
Autores principales: Rock, Jeremy M., Lang, Ulla F., Chase, Michael R., Ford, Christopher B., Gerrick, Elias R., Gawande, Richa, Coscolla, Mireia, Gagneux, Sebastien, Fortune, Sarah M., Lamers, Meindert H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449270/
https://www.ncbi.nlm.nih.gov/pubmed/25894501
http://dx.doi.org/10.1038/ng.3269

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449270/
https://www.ncbi.nlm.nih.gov/pubmed/25894501
http://dx.doi.org/10.1038/ng.3269

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