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Improved genome inference in the MHC using a population reference graph
While much is known about human genetic variation, such information is typically ignored in assembling novel genomes. Instead, reads are mapped to a single reference, which can lead to poor characterization of regions of high sequence or structural diversity. We introduce a population reference grap...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449272/ https://www.ncbi.nlm.nih.gov/pubmed/25915597 http://dx.doi.org/10.1038/ng.3257 |