Optimization of Fermentation Conditions for Recombinant Human Interferon Beta Production by Escherichia coli Using the Response Surface Methodology

BACKGROUND: The periplasmic overexpression of recombinant human interferon beta (rhIFN-β)-1b using a synthetic gene in Escherichia coli BL21 (DE3) was optimized in shake flasks using Response Surface Methodology (RSM) based on the Box-Behnken Design (BBD). OBJECTIVES: This study aimed to predict and...

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Detalles Bibliográficos
Autores principales: Morowvat, Mohammad Hossein, Babaeipour, Valiollah, Rajabi Memari, Hamid, Vahidi, Hossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kowsar 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449858/
https://www.ncbi.nlm.nih.gov/pubmed/26034535
http://dx.doi.org/10.5812/jjm.8(4)2015.16236

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449858/
https://www.ncbi.nlm.nih.gov/pubmed/26034535
http://dx.doi.org/10.5812/jjm.8(4)2015.16236

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