Cargando…

Manipulating Adenovirus Hexon Hypervariable Loops Dictates Immune Neutralisation and Coagulation Factor X-dependent Cell Interaction In Vitro and In Vivo

Adenoviruses are common pathogens, mostly targeting ocular, gastrointestinal and respiratory cells, but in some cases infection disseminates, presenting in severe clinical outcomes. Upon dissemination and contact with blood, coagulation factor X (FX) interacts directly with the adenovirus type 5 (Ad...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ma, Jiangtao, Duffy, Margaret R., Deng, Lin, Dakin, Rachel S., Uil, Taco, Custers, Jerome, Kelly, Sharon M., McVey, John H., Nicklin, Stuart A., Baker, Andrew H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450073/ https://www.ncbi.nlm.nih.gov/pubmed/25658827 http://dx.doi.org/10.1371/journal.ppat.1004673

Ejemplares similares

Retargeting FX-binding-ablated HAdV-5 to vascular cells by inclusion of the RGD-4C peptide in hexon hypervariable region 7 and the HI loop
por: Robertson, Stacy, et al.
Publicado: (2016)

HIV Antigen Incorporation within Adenovirus Hexon Hypervariable 2 for a Novel HIV Vaccine Approach
por: Matthews, Qiana L., et al.
Publicado: (2010)

Hydropathic characteristics of adenovirus hexons
por: Li, Q.-G., et al.
Publicado: (1997)

Biodistribution and inflammatory profiles of novel penton and hexon double-mutant serotype 5 adenoviruses
por: Bradshaw, Angela C., et al.
Publicado: (2012)

Binding of adenovirus species C hexon to prothrombin and the influence of hexon on vector properties in vitro and in vivo
por: Tian, Jie, et al.
Publicado: (2022)

The relevance of coagulation factor X protection of adenoviruses in human sera
por: Duffy, M R, et al.
Publicado: (2016)

Worldwide increased prevalence of human adenovirus type 3 (HAdV-3) respiratory infections is well correlated with heterogeneous hypervariable regions (HVRs) of hexon
por: Haque, Ezazul, et al.
Publicado: (2018)

Correction: Worldwide increased prevalence of human adenovirus type 3 (HAdV-3) respiratory infections is well correlated with heterogeneous hypervariable regions (HVRs) of hexon
por: Haque, Ezazul, et al.
Publicado: (2018)

Exploration of New Sites in Adenovirus Hexon for Foreign Peptides Insertion
por: Hansra, Satyender, et al.
Publicado: (2015)

Determination of different antigenic sites on the adenovirus hexon using monoclonal antibodies
por: Ádám, Éva, et al.
Publicado: (1987)

Immunological Study of Reconstructed Common Ancestral Sequence of Adenovirus Hexon Protein
por: Wang, Yingchen, et al.
Publicado: (2021)

P17-13. Hexon hypervariable regions 4–7 contain important Ad5-specific neutralizing antibody epitopes
por: Bradley, RR, et al.
Publicado: (2009)

Identification and Application of Neutralizing Epitopes of Human Adenovirus Type 55 Hexon Protein
por: Tian, Xingui, et al.
Publicado: (2015)

Identification of a novel immunological epitope on Hexon of fowl adenovirus serotype 4
por: Liu, Jingyi, et al.
Publicado: (2021)

Modification of Ad5 Hexon Hypervariable Regions Circumvents Pre-Existing Ad5 Neutralizing Antibodies and Induces Protective Immune Responses
por: Bruder, Joseph T., et al.
Publicado: (2012)

Requirements for Receptor Engagement during Infection by Adenovirus Complexed with Blood Coagulation Factor X
por: Bradshaw, Angela C., et al.
Publicado: (2010)

Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions
por: Baker, Alexander T., et al.
Publicado: (2019)

Human Adenovirus Serotype 3 Vector Packaged by a Rare Serotype 14 Hexon
por: Su, Xiaobo, et al.
Publicado: (2016)

Identification of a Critical and Conformational Neutralizing Epitope in Human Adenovirus Type 4 Hexon
por: Tian, Xingui, et al.
Publicado: (2018)

Lactoferrin-Hexon Interactions Mediate CAR-Independent Adenovirus Infection of Human Respiratory Cells
por: Persson, B. David, et al.
Publicado: (2020)

Icosahedral gold nanoparticles decorated with hexon protein: a surrogate for adenovirus serotype 5
por: Fresco-Cala, Beatriz, et al.
Publicado: (2022)

Hexons from adenovirus serotypes 5 and 48 differentially protect adenovirus vectors from neutralization by mouse and human serum
por: Harmon, Andrew W., et al.
Publicado: (2018)

Correction: Modification of Ad5 Hexon Hypervariable Regions Circumvents Pre-Existing Ad5 Neutralizing Antibodies and Induces Protective Immune Responses
por: Bruder, Joseph T., et al.
Publicado: (2012)

Protection against Enterovirus 71 with Neutralizing Epitope Incorporation within Adenovirus Type 3 Hexon
por: Tian, Xingui, et al.
Publicado: (2012)

Traceless Bioresponsive Shielding of Adenovirus Hexon with HPMA Copolymers Maintains Transduction Capacity In Vitro and In Vivo
por: Prill, Jan-Michael, et al.
Publicado: (2014)

Recombinant Hexon Protein as a New Bovine Adenovirus Type 3 Subunit Vaccine Candidate
por: Gundegmaa, Uudamsaikhan, et al.
Publicado: (2023)

Influence of zinc on glycosaminoglycan neutralisation during coagulation
por: Sobczak, Amélie I. S., et al.
Publicado: (2018)

Deep analysis of Loop L1 HVRs1-4 region of the hexon gene of adenovirus field strains isolated in Poland
por: Niczyporuk, Jowita Samanta
Publicado: (2018)

Adenovirus Recruits Dynein by an Evolutionary Novel Mechanism Involving Direct Binding to pH-Primed Hexon
por: Scherer, Julian, et al.
Publicado: (2011)

Transcellular Targeting of Fiber- and Hexon-Modified Adenovirus Vectors across the Brain Microvascular Endothelial Cells In Vitro
por: Laakkonen, Johanna P., et al.
Publicado: (2012)

Correction: Protection against Enterovirus 71 with Neutralizing Epitope Incorporation within Adenovirus Type 3 Hexon
por: Tian, Xingui, et al.
Publicado: (2012)

Hexon Modification to Improve the Activity of Oncolytic Adenovirus Vectors against Neoplastic and Stromal Cells in Pancreatic Cancer
por: Lucas, Tanja, et al.
Publicado: (2015)

Fiber2 and hexon genes are closely associated with the virulence of the emerging and highly pathogenic fowl adenovirus 4
por: Zhang, Yuhan, et al.
Publicado: (2018)

The Role of Hexon Amino Acid 188 Varies in Fowl Adenovirus Serotype 4 Strains with Different Virulence
por: Wang, Baiyu, et al.
Publicado: (2022)

Efficient Transduction of Primary Vascular Cells by the Rare Adenovirus Serotype 49 Vector
por: Dakin, Rachel S., et al.
Publicado: (2015)

Genetic Analysis of a Novel Human Adenovirus with a Serologically Unique Hexon and a Recombinant Fiber Gene
por: Liu, Elizabeth B., et al.
Publicado: (2011)

Correction: Hexon Modification to Improve the Activity of Oncolytic Adenovirus Vectors against Neoplastic and Stromal Cells in Pancreatic Cancer
Publicado: (2015)

Identification of Two Novel Linear Neutralizing Epitopes within the Hexon Protein of Canine Adenovirus Using Monoclonal Antibodies
por: Wang, Shujie, et al.
Publicado: (2021)

Hexon and fiber gene changes in an attenuated fowl adenovirus isolate from Malaysia in embryonated chicken eggs and its infectivity in chickens
por: Sohaimi, Norfitriah M., et al.
Publicado: (2018)

Structure-Based High-Throughput Epitope Analysis of Hexon Proteins in B and C Species Human Adenoviruses (HAdVs)
por: Yuan, Xiao-Hui, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_09qk1u9h7hipnikup2vbtlk86q