IFNγ Signaling Endows DCs with the Capacity to Control Type I Inflammation during Parasitic Infection through Promoting T-bet+ Regulatory T Cells

IFNγ signaling drives dendritic cells (DCs) to promote type I T cell (Th1) immunity. Here, we show that activation of DCs by IFNγ is equally crucial for the differentiation of a population of T-bet+ regulatory T (Treg) cells specialized to inhibit Th1 immune responses. Conditional deletion of IFNγ r...

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Detalles Bibliográficos
Autores principales: Lee, Hyang-Mi, Fleige, Anne, Forman, Ruth, Cho, Sunglim, Khan, Aly Azeem, Lin, Ling-Li, Nguyen, Duc T., O'Hara-Hall, Aisling, Yin, Zhinan, Hunter, Christopher A., Muller, Werner, Lu, Li-Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450074/
https://www.ncbi.nlm.nih.gov/pubmed/25658840
http://dx.doi.org/10.1371/journal.ppat.1004635

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450074/
https://www.ncbi.nlm.nih.gov/pubmed/25658840
http://dx.doi.org/10.1371/journal.ppat.1004635

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