Cargando…

Structural constraints on the evolution of the collagen fibril: convergence on a 1014-residue COL domain

Type I collagen is the fundamental component of the extracellular matrix. Its α1 gene is the direct descendant of ancestral fibrillar collagen and contains 57 exons encoding the rod-like triple-helical COL domain. We trace the evolution of the COL domain from a primordial collagen 18 residues in len...

Descripción completa

Detalles Bibliográficos
Autores principales: Slatter, David Anthony, Farndale, Richard William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450265/
https://www.ncbi.nlm.nih.gov/pubmed/25994354
http://dx.doi.org/10.1098/rsob.140220