C7β-Methyl Analogues of the Orvinols: The Discovery of Kappa Opioid Antagonists with Nociceptin/Orphanin FQ Peptide (NOP) Receptor Partial Agonism and Low, or Zero, Efficacy at Mu Opioid Receptors

[Image: see text] Buprenorphine is a successful analgesic and treatment for opioid abuse, with both activities relying on its partial agonist activity at mu opioid receptors. However, there is substantial interest in its activities at the kappa opioid and nociceptin/orphanin FQ peptide receptors. Th...

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Detalles Bibliográficos
Autores principales: Cueva, Juan Pablo, Roche, Christopher, Ostovar, Mehrnoosh, Kumar, Vinod, Clark, Mary J., Hillhouse, Todd M., Lewis, John W., Traynor, John R., Husbands, Stephen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450370/
https://www.ncbi.nlm.nih.gov/pubmed/25898137
http://dx.doi.org/10.1021/acs.jmedchem.5b00130

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450370/
https://www.ncbi.nlm.nih.gov/pubmed/25898137
http://dx.doi.org/10.1021/acs.jmedchem.5b00130

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