Nontoxic singlet oxygen generator as a therapeutic candidate for treating tauopathies

Methylene blue (MB) inhibits the aggregation of tau, a main constituent of neurofibrillary tangles. However, MB’s mode of action in vivo is not fully understood. MB treatment reduced the amount of sarkosyl-insoluble tau in Drosophila that express human wild-type tau. MB concurrently ameliorated the...

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Detalles Bibliográficos
Autores principales: Sheik Mohideen, Sahabudeen, Yamasaki, Yasutoyo, Omata, Yasuhiro, Tsuda, Leo, Yoshiike, Yuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450544/
https://www.ncbi.nlm.nih.gov/pubmed/26027742
http://dx.doi.org/10.1038/srep10821

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450544/
https://www.ncbi.nlm.nih.gov/pubmed/26027742
http://dx.doi.org/10.1038/srep10821

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