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The Wnt5a-Ror2 axis promotes the signaling circuit between interleukin-12 and interferon-γ in colitis
Wnt5a, which regulates various cellular functions in Wnt signaling, is involved in inflammatory responses, however the mechanism is not well understood. We examined the role of Wnt5a signaling in intestinal immunity using conditional knockout mice for Wnt5a and its receptor Ror2. Removing Wnt5a or R...
Autores principales: | Sato, Akira, Kayama, Hisako, Shojima, Kensaku, Matsumoto, Shinji, Koyama, Hirofumi, Minami, Yasuhiro, Nojima, Satoshi, Morii, Eiichi, Honda, Hiroaki, Takeda, Kiyoshi, Kikuchi, Akira |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450756/ https://www.ncbi.nlm.nih.gov/pubmed/26030277 http://dx.doi.org/10.1038/srep10536 |
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