SAMHD1 specifically restricts retroviruses through its RNase activity

BACKGROUND: Human SAMHD1 possesses dual enzymatic functions. It acts as both a dGTP-dependent triphosphohydrolase and as an exoribonuclease. The dNTPase function depletes the cellular dNTP pool, which is required for retroviral reverse transcription in differentiated myeloid cells and resting CD4(+)...

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Detalles Bibliográficos
Autores principales: Choi, Jongsu, Ryoo, Jeongmin, Oh, Changhoon, Hwang, Sungyeon, Ahn, Kwangseog
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450836/
https://www.ncbi.nlm.nih.gov/pubmed/26032178
http://dx.doi.org/10.1186/s12977-015-0174-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450836/
https://www.ncbi.nlm.nih.gov/pubmed/26032178
http://dx.doi.org/10.1186/s12977-015-0174-4

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