Lack of Protection Against Ebola Virus from Chloroquine in Mice and Hamsters

The antimalarial drug chloroquine has been suggested as a treatment for Ebola virus infection. Chloroquine inhibited virus replication in vitro, but only at cytotoxic concentrations. In mouse and hamster models, treatment did not improve survival. Chloroquine is not a promising treatment for Ebola....

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Detalles Bibliográficos
Autores principales: Falzarano, Darryl, Safronetz, David, Prescott, Joseph, Marzi, Andrea, Feldmann, Friederike, Feldmann, Heinz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2015
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451918/
https://www.ncbi.nlm.nih.gov/pubmed/25988934
http://dx.doi.org/10.3201/eid2106.150176
Descripción
Sumario:The antimalarial drug chloroquine has been suggested as a treatment for Ebola virus infection. Chloroquine inhibited virus replication in vitro, but only at cytotoxic concentrations. In mouse and hamster models, treatment did not improve survival. Chloroquine is not a promising treatment for Ebola. Efforts should be directed toward other drug classes.

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