Jnk2 promotes stress-induced mitophagy and suppresses inflammasome activation by targeting smARF for degradation

Mitophagy is essential for cellular homeostasis but the regulatory mechanism is largely unknown. Here we report that the kinase Jnk2 is required for stress-induced mitophagy. Jnk2 promoted ubiquitination and proteasomal degradation of small mitochondrial form of ARF (smARF). Loss of Jnk2 led to accu...

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Detalles Bibliográficos
Autores principales: Zhang, Qiao, Kuang, Hong, Chen, Cong, Yan, Jie, Do-Umehara, Hanh Chi, Liu, Xin-yuan, Dada, Laura, Ridge, Karen M., Chandel, Navdeep S., Liu, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451949/
https://www.ncbi.nlm.nih.gov/pubmed/25799126
http://dx.doi.org/10.1038/ni.3130

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451949/
https://www.ncbi.nlm.nih.gov/pubmed/25799126
http://dx.doi.org/10.1038/ni.3130

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