microRNA therapies in cancer
MicroRNAs (miRNAs or miRs) are a family of small non-coding RNA species that have been implicated in the control of many fundamental cellular and physiological processes such as cellular differentiation, proliferation, apoptosis and stem cell maintenance. miRNAs regulate gene expression by the seque...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452061/ https://www.ncbi.nlm.nih.gov/pubmed/26056576 http://dx.doi.org/10.1186/2052-8426-2-7 |
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author | Rothschild, Sacha I |
author_facet | Rothschild, Sacha I |
author_sort | Rothschild, Sacha I |
collection | PubMed |
description | MicroRNAs (miRNAs or miRs) are a family of small non-coding RNA species that have been implicated in the control of many fundamental cellular and physiological processes such as cellular differentiation, proliferation, apoptosis and stem cell maintenance. miRNAs regulate gene expression by the sequence-selective targeting of mRNAs, leading to translational repression or mRNA degradation. Some microRNAs have been categorized as “oncomiRs” as opposed to “tumor suppressor miRs” Modulating the miRNA activities may provide exciting opportunities for cancer therapy. This review highlights the latest discovery of miRNAs involved in carcinogenesis as well as the potential applications of miRNA regulations in cancer treatment. Several studies have demonstrated the feasibility of restoring tumor suppressive miRNAs and targeting oncogenic miRNAs for cancer therapy using in vivo model systems. |
format | Online Article Text |
id | pubmed-4452061 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-44520612015-06-09 microRNA therapies in cancer Rothschild, Sacha I Mol Cell Ther Review MicroRNAs (miRNAs or miRs) are a family of small non-coding RNA species that have been implicated in the control of many fundamental cellular and physiological processes such as cellular differentiation, proliferation, apoptosis and stem cell maintenance. miRNAs regulate gene expression by the sequence-selective targeting of mRNAs, leading to translational repression or mRNA degradation. Some microRNAs have been categorized as “oncomiRs” as opposed to “tumor suppressor miRs” Modulating the miRNA activities may provide exciting opportunities for cancer therapy. This review highlights the latest discovery of miRNAs involved in carcinogenesis as well as the potential applications of miRNA regulations in cancer treatment. Several studies have demonstrated the feasibility of restoring tumor suppressive miRNAs and targeting oncogenic miRNAs for cancer therapy using in vivo model systems. BioMed Central 2014-03-04 /pmc/articles/PMC4452061/ /pubmed/26056576 http://dx.doi.org/10.1186/2052-8426-2-7 Text en © Rothschild; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Rothschild, Sacha I microRNA therapies in cancer |
title | microRNA therapies in cancer |
title_full | microRNA therapies in cancer |
title_fullStr | microRNA therapies in cancer |
title_full_unstemmed | microRNA therapies in cancer |
title_short | microRNA therapies in cancer |
title_sort | microrna therapies in cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452061/ https://www.ncbi.nlm.nih.gov/pubmed/26056576 http://dx.doi.org/10.1186/2052-8426-2-7 |
work_keys_str_mv | AT rothschildsachai micrornatherapiesincancer |