Cargando…

Validation study of the combined repeated-dose toxicity and genotoxicity assay using gpt delta rats

Transgenic rodents carrying reporter genes to detect organ-specific in vivo genetic alterations are useful for risk assessment of genotoxicity that causes cancer. Thus, the Organization for Economic Co-operation and Development has established the guideline for genotoxicity tests using transgenic an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Akagi, Jun-ichi, Toyoda, Takeshi, Cho, Young-Man, Mizuta, Yasuko, Nohmi, Takehiko, Nishikawa, Akiyoshi, Ogawa, Kumiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2015
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452153/ https://www.ncbi.nlm.nih.gov/pubmed/25683344 http://dx.doi.org/10.1111/cas.12634

Ejemplares similares

Genotoxic responses to titanium dioxide nanoparticles and fullerene in gpt delta transgenic MEF cells
por: Xu, An, et al.
Publicado: (2009)

Integration of In Vivo Genotoxicity and Short-term Carcinogenicity Assays Using F344 gpt Delta Transgenic Rats: In Vivo Mutagenicity of 2,4-Diaminotoluene and 2,6-Diaminotoluene Structural Isomers
por: Toyoda-Hokaiwado, Naomi, et al.
Publicado: (2010)

Development of a Medium-term Animal Model Using gpt Delta Rats to Evaluate Chemical Carcinogenicity and Genotoxicity
por: Matsushita, Kohei, et al.
Publicado: (2013)

Genomic integration of lambda EG10 transgene in gpt delta transgenic rodents
por: Masumura, Kenichi, et al.
Publicado: (2015)

Size-dependent acute toxicity of silver nanoparticles in mice
por: Cho, Young-Man, et al.
Publicado: (2017)

New Insight into Intrachromosomal Deletions Induced by Chrysotile in the gpt delta Transgenic Mutation Assay
por: Xu, An, et al.
Publicado: (2007)

Background data of 2-year-old male and female F344 gpt delta rats
por: Matsushita, Kohei, et al.
Publicado: (2020)

Mutagenicity of carcinogenic heterocyclic amines in Salmonella typhimurium YG strains and transgenic rodents including gpt delta
por: Nohmi, Takehiko, et al.
Publicado: (2021)

Oral toxicological study of titanium dioxide nanoparticles with a crystallite diameter of 6 nm in rats
por: Akagi, Jun-ichi, et al.
Publicado: (2023)

Estimation of the frequency of inherited germline mutations by whole exome sequencing in ethyl nitrosourea-treated and untreated gpt delta mice
por: Masumura, Kenichi, et al.
Publicado: (2016)

Thresholds of Genotoxic and Non-Genotoxic Carcinogens
por: Nohmi, Takehiko
Publicado: (2018)

New homozygous gpt delta transgenic rat strain improves an efficiency of the in vivo mutagenicity assay
por: Masumura, Kenichi, et al.
Publicado: (2021)

Role of oxidative stress in the chemical structure-related genotoxicity of nitrofurantoin in Nrf2-deficient gpt delta mice
por: Tsuchiya, Takuma, et al.
Publicado: (2018)

Detection of γ-H2AX, a Biomarker for DNA Double-strand Breaks, in Urinary Bladders of N -Butyl- N -(4-Hydroxybutyl)-Nitrosamine-Treated Rats
por: Toyoda, Takeshi, et al.
Publicado: (2013)

Effects of the scid mutation on X-ray-induced deletions in the brain and spleen of gpt delta mice
por: Masumura, Kenichi, et al.
Publicado: (2020)

Characteristic mutations induced in the small intestine of Msh2-knockout gpt delta mice
por: Aoki, Yasunobu, et al.
Publicado: (2021)

Genotoxicity of nano/microparticles in in vitro micronuclei, in vivo comet and mutation assay systems
por: Totsuka, Yukari, et al.
Publicado: (2009)

Alterations in the mutagenicity and mutation spectrum induced by benzo[a]pyrene instilled in the lungs of gpt delta mice of various ages
por: Aoki, Yasunobu, et al.
Publicado: (2015)

A 13-week subchronic toxicity study of hexyl acetate in SD rats
por: Toyoda, Takeshi, et al.
Publicado: (2019)

Using FFPE RNA-Seq with 12 marker genes to evaluate genotoxic and non-genotoxic rat hepatocarcinogens
por: Furihata, Chie, et al.
Publicado: (2020)

Change over time of the mutagenicity in the lungs of gpt delta transgenic mice by extract of airborne particles collected from ambient air in the Tokyo metropolitan area
por: Aoki, Yasunobu, et al.
Publicado: (2018)

Genotoxicity assessment of titanium dioxide nanoparticle accumulation of 90 days in the liver of gpt delta transgenic mice
por: Suzuki, Tetsuya, et al.
Publicado: (2020)

Correction to: Genotoxicity assessment of titanium dioxide nanoparticle accumulation of 90 days in the liver of gpt delta transgenic mice
por: Suzuki, Tetsuya, et al.
Publicado: (2020)

Genotoxicity and repeated-dose toxicity evaluation of dried Wolffia globosa Mankai
por: Kawamata, Yasuko, et al.
Publicado: (2020)

Radiation induced COX-2 expression and mutagenesis at non-targeted lung tissues of gpt delta transgenic mice
por: Chai, Y, et al.
Publicado: (2013)

4-Methylthio-3-butenyl isothiocyanate (raphasatin) exerts chemopreventive effects against esophageal carcinogenesis in rats
por: Suzuki, Isamu, et al.
Publicado: (2016)

Biostatistical issues in the design and analysis of multiple or repeated genotoxicity assays.
por: Edler, L
Publicado: (1994)

Single and Repeated Oral Dose Toxicity and Genotoxicity of the Leaves of Butterbur
por: Park, Sangsu, et al.
Publicado: (2021)

Transgenic rat models for mutagenesis and carcinogenesis
por: Nohmi, Takehiko, et al.
Publicado: (2017)

Dimethylarsinic acid may promote prostate carcinogenesis in rats
por: Suzuki, Shugo, et al.
Publicado: (2018)

Assessment of the 4‐week repeated‐dose oral toxicity and genotoxicity of GHX02
por: Ji, Kon‐Young, et al.
Publicado: (2019)

Genotoxicity and 28-day repeated dose oral toxicity study of ovatodiolide in rats
por: Chen, Jing-Chun, et al.
Publicado: (2021)

DNA polymerase kappa protects human cells against MMC-induced genotoxicity through error-free translesion DNA synthesis
por: Kanemaru, Yuki, et al.
Publicado: (2017)

Undifferentiated Sarcoma of the Salivary Gland in a Mongolian Gerbil (Meriones unguiculatus)
por: Toyoda, Takeshi, et al.
Publicado: (2011)

A 13-week subchronic toxicity study of 2-(l-menthoxy)ethanol in F344 rats
por: Toyoda, Takeshi, et al.
Publicado: (2021)

Single, repeated dose toxicity and genotoxicity assessment of herb formula KIOM2012H
por: Park, Hwayong, et al.
Publicado: (2017)

Early detection of urinary bladder carcinogens in rats by immunohistochemistry for γ-H2AX: a review from analyses of 100 chemicals
por: Toyoda, Takeshi, et al.
Publicado: (2022)

Genotoxicity and 28-day repeated dose oral toxicity study of garlic essential oil in mice
por: Lin, Yu-En, et al.
Publicado: (2022)

Greetings from The International Association of Environmental Mutagenesis and Genomics Societies
por: Nohmi, Takehiko
Publicado: (2015)

Purification and interactions of the MucA’ and MucB proteins constituting the DNA polymerase RI
por: Grúz, Petr, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_gu6ko00ladfe2rqn03c1fi46rs