Natural Variants of the KPC-2 Carbapenemase have Evolved Increased Catalytic Efficiency for Ceftazidime Hydrolysis at the Cost of Enzyme Stability

The spread of β-lactamases that hydrolyze penicillins, cephalosporins and carbapenems among Gram-negative bacteria has limited options for treating bacterial infections. Initially, Klebsiella pneumoniae carbapenemase-2 (KPC-2) emerged as a widespread carbapenem hydrolyzing β-lactamase that also hydr...

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Detalles Bibliográficos
Autores principales: Mehta, Shrenik C., Rice, Kacie, Palzkill, Timothy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452179/
https://www.ncbi.nlm.nih.gov/pubmed/26030609
http://dx.doi.org/10.1371/journal.ppat.1004949

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452179/
https://www.ncbi.nlm.nih.gov/pubmed/26030609
http://dx.doi.org/10.1371/journal.ppat.1004949

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