Investigation of the Physico-Chemical Properties that Enable Co-Formulation of Basal Insulin Degludec with Fast-Acting Insulin Aspart

PURPOSE: To study the self-association states of insulin degludec and insulin aspart alone and combined in pharmaceutical formulation and under conditions simulating the subcutaneous depot. METHODS: Formulations were made of 0.6 mM degludec at 3 and 5 Zn/6 insulin monomers, and 0.6 mM aspart (2 Zn/6...

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Detalles Bibliográficos
Autores principales: Havelund, Svend, Ribel, Ulla, Hubálek, František, Hoeg-Jensen, Thomas, Wahlund, Per-Olof, Jonassen, Ib
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452210/
https://www.ncbi.nlm.nih.gov/pubmed/25563978
http://dx.doi.org/10.1007/s11095-014-1614-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452210/
https://www.ncbi.nlm.nih.gov/pubmed/25563978
http://dx.doi.org/10.1007/s11095-014-1614-x

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