Nanoparticulate Impurities in Pharmaceutical-Grade Sugars and their Interference with Light Scattering-Based Analysis of Protein Formulations

PURPOSE: In the present study we investigated the root-cause of an interference signal (100–200 nm) of sugar-containing solutions in dynamic light scattering (DLS) and nanoparticle tracking analysis (NTA) and its consequences for the analysis of particles in biopharmaceutical drug products. METHODS:...

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Detalles Bibliográficos
Autores principales: Weinbuch, Daniel, Cheung, Jason K., Ketelaars, Jurgen, Filipe, Vasco, Hawe, Andrea, den Engelsman, John, Jiskoot, Wim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452213/
https://www.ncbi.nlm.nih.gov/pubmed/25630820
http://dx.doi.org/10.1007/s11095-015-1634-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452213/
https://www.ncbi.nlm.nih.gov/pubmed/25630820
http://dx.doi.org/10.1007/s11095-015-1634-1

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