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Detailed Per-residue Energetic Analysis Explains the Driving Force for Microtubule Disassembly
Microtubules are long filamentous hollow cylinders whose surfaces form lattice structures of αβ-tubulin heterodimers. They perform multiple physiological roles in eukaryotic cells and are targets for therapeutic interventions. In our study, we carried out all-atom molecular dynamics simulations for...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452272/ https://www.ncbi.nlm.nih.gov/pubmed/26030285 http://dx.doi.org/10.1371/journal.pcbi.1004313 |