Functional Assessment of Disease-Associated Regulatory Variants In Vivo Using a Versatile Dual Colour Transgenesis Strategy in Zebrafish

Disruption of gene regulation by sequence variation in non-coding regions of the genome is now recognised as a significant cause of human disease and disease susceptibility. Sequence variants in cis-regulatory elements (CREs), the primary determinants of spatio-temporal gene regulation, can alter tr...

Descripción completa

Detalles Bibliográficos
Autores principales: Bhatia, Shipra, Gordon, Christopher T., Foster, Robert G., Melin, Lucie, Abadie, Véronique, Baujat, Geneviève, Vazquez, Marie-Paule, Amiel, Jeanne, Lyonnet, Stanislas, van Heyningen, Veronica, Kleinjan, Dirk A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452300/
https://www.ncbi.nlm.nih.gov/pubmed/26030420
http://dx.doi.org/10.1371/journal.pgen.1005193

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452300/
https://www.ncbi.nlm.nih.gov/pubmed/26030420
http://dx.doi.org/10.1371/journal.pgen.1005193

Ejemplares similares