Secreted Frizzled-Related Protein 4 Inhibits Glioma Stem-Like Cells by Reversing Epithelial to Mesenchymal Transition, Inducing Apoptosis and Decreasing Cancer Stem Cell Properties

The Wnt pathway is integrally involved in regulating self-renewal, proliferation, and maintenance of cancer stem cells (CSCs). We explored the effect of the Wnt antagonist, secreted frizzled-related protein 4 (sFRP4), in modulating epithelial to mesenchymal transition (EMT) in CSCs from human gliobl...

Descripción completa

Detalles Bibliográficos
Autores principales: G, Bhuvanalakshmi, Arfuso, Frank, Millward, Michael, Dharmarajan, Arun, Warrier, Sudha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452329/
https://www.ncbi.nlm.nih.gov/pubmed/26030909
http://dx.doi.org/10.1371/journal.pone.0127517

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452329/
https://www.ncbi.nlm.nih.gov/pubmed/26030909
http://dx.doi.org/10.1371/journal.pone.0127517

Ejemplares similares