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Impaired Fracture Healing Caused by Deficiency of the Immunoreceptor Adaptor Protein DAP12

Osteoclasts play an important role in bone metabolism, but their exact role in fracture healing remains unclear. DAP12 is an immunoadaptor protein with associated immunoreceptors on myeloid lineage cells, including osteoclasts. Its deficiency causes osteopetrosis due to suppression of osteoclast dev...

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Detalles Bibliográficos
Autores principales: Kamimura, Masayuki, Mori, Yu, Sugahara-Tobinai, Akiko, Takai, Toshiyuki, Itoi, Eiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452492/
https://www.ncbi.nlm.nih.gov/pubmed/26030755
http://dx.doi.org/10.1371/journal.pone.0128210