ABC transporter-dependent brain uptake of the 5-HT(1B) receptor radioligand [(11)C]AZ10419369: a comparative PET study in mouse, rat, and guinea pig

BACKGROUND: We have explored the possibility that the serotonin 1B receptor radioligand [(11)C]AZ10419369 is a substrate for adenosine triphosphate (ATP)-binding cassette (ABC) transporters, such as P-glycoprotein (P-gp), Mrp4, and Bcrp, in rodents and whether there is a species difference regarding...

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Detalles Bibliográficos
Autores principales: Tóth, Miklós, Häggkvist, Jenny, Varrone, Andrea, Finnema, Sjoerd J, Doorduin, Janine, Tokunaga, Masaki, Higuchi, Makoto, Gulyás, Balázs, Halldin, Christer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452686/
https://www.ncbi.nlm.nih.gov/pubmed/26116125
http://dx.doi.org/10.1186/s13550-014-0064-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452686/
https://www.ncbi.nlm.nih.gov/pubmed/26116125
http://dx.doi.org/10.1186/s13550-014-0064-0

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