Mitotic Slippage and Expression of Survivin Are Linked to Differential Sensitivity of Human Cancer Cell-Lines to the Kinesin-5 Inhibitor Monastrol

The mitotic Kinesin-5 motor proteins crosslink and slide apart antiparallel spindle microtubules, thus performing essential functions in mitotic spindle dynamics. Specific inhibition of their function by monastrol-like small molecules has been examined in clinical trials as anticancer treatment, wit...

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Detalles Bibliográficos
Autores principales: Asraf, Hila, Avunie-Masala, Rachel, Hershfinkel, Michal, Gheber, Larisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452773/
https://www.ncbi.nlm.nih.gov/pubmed/26035434
http://dx.doi.org/10.1371/journal.pone.0129255

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452773/
https://www.ncbi.nlm.nih.gov/pubmed/26035434
http://dx.doi.org/10.1371/journal.pone.0129255

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