GLI2-dependent c-MYC upregulation mediates resistance of pancreatic cancer cells to the BET bromodomain inhibitor JQ1

JQ1 and I-BET151 are selective inhibitors of BET bromodomain proteins that have efficacy against a number of different cancers. Since the effectiveness of targeted therapies is often limited by development of resistance, we examined whether it was possible for cancer cells to develop resistance to t...

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Detalles Bibliográficos
Autores principales: Kumar, Krishan, Raza, Sania S., Knab, Lawrence M., Chow, Christina R., Kwok, Benjamin, Bentrem, David J., Popovic, Relja, Ebine, Kazumi, Licht, Jonathan D., Munshi, Hidayatullah G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452877/
https://www.ncbi.nlm.nih.gov/pubmed/25807524
http://dx.doi.org/10.1038/srep09489

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452877/
https://www.ncbi.nlm.nih.gov/pubmed/25807524
http://dx.doi.org/10.1038/srep09489

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