Examining kinesin processivity within a general gating framework

Kinesin-1 is a dimeric motor that transports cargo along microtubules, taking 8.2-nm steps in a hand-over-hand fashion. The ATP hydrolysis cycles of its two heads are maintained out of phase by a series of gating mechanisms, which lead to processive runs averaging ∼1 μm. A key structural element for...

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Detalles Bibliográficos
Autores principales: Andreasson, Johan OL, Milic, Bojan, Chen, Geng-Yuan, Guydosh, Nicholas R, Hancock, William O, Block, Steven M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453223/
https://www.ncbi.nlm.nih.gov/pubmed/25902401
http://dx.doi.org/10.7554/eLife.07403

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453223/
https://www.ncbi.nlm.nih.gov/pubmed/25902401
http://dx.doi.org/10.7554/eLife.07403

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